Pectin with various degrees of esterification differentially alters gut microbiota and metabolome of healthy adults

Correlation of gut microbiota composition with colon adenomatous polyps

Microbiota is a collection of microorganisms that live in the oral cavity, respiratory tract and intestine of multicellular organisms. Microbiota exerts numerous physiological and pathological effects on the organism in which it resides. Increasing attention has been directed to the host-microbiota interaction, which is highly relevant to the development of carcinogenesis. Changes in the compos...

Oral supplementation with L-glutamine alters gut microbiota of obese and overweight adults: A pilot study.

OBJECTIVE The aim of this study was to determine whether oral supplementation with L-glutamine (GLN) modifies the gut microbiota composition in overweight and obese adults. METHODS Thirty-three overweight and obese adults, ages between 23 and 59 y and body mass index between 25.03 and 47.12 kg/m(2), were randomly assigned to receive either oral supplementation with 30 g of L-alanine (ALA grou...

Preterm gut microbiota and metabolome following discharge from intensive care

The development of the preterm gut microbiome is important for immediate and longer-term health following birth. We aimed to determine if modifications to the preterm gut on the neonatal intensive care unit (NICU) impacted the gut microbiota and metabolome long-term. Stool samples were collected from 29 infants ages 1-3 years post discharge (PD) from a single NICU. Additional NICU samples were ...

Gut Microbiota and Neuropsychiatric Disorders

Oral versus intravenous iron replacement therapy distinctly alters the gut microbiota and metabolome in patients with IBD

OBJECTIVE Iron deficiency is a common complication in patients with IBD and oral iron therapy is suggested to exacerbate IBD symptoms. We performed an open-labelled clinical trial to compare the effects of per oral (PO) versus intravenous (IV) iron replacement therapy (IRT). DESIGN The study population included patients with Crohn's disease (CD; N=31), UC (N=22) and control subjects with iron...